Generation of Fgfr3 Conditional Knockout Mice
نویسندگان
چکیده
منابع مشابه
Generation of Fgfr3 Conditional Knockout Mice
Fibroblast growth factor receptor 3 (FGFR3), highly conserved in both humans and murine, is one of key tyrosine kinase receptors for FGF. FGFR3 is expressed in different tissues, including cartilage, brain, kidney, and intestine at different development stages. Conventional knockout of Fgfr3 alleles leads to short life span, and overgrowth of bone. In clinic, human FGFR3 mutations are responsib...
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Recently, neurotrophic factors and cytokines have been shown to be associated in psychiatric disorders, such as schizophrenia, bipolar disorder, and depression. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family, serves as a neurotrophic molecular and plays a significant role in the brain. We generated mice in which HB-EGF activity is disrupted spe...
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ژورنال
عنوان ژورنال: International Journal of Biological Sciences
سال: 2010
ISSN: 1449-2288
DOI: 10.7150/ijbs.6.327